Current in OW you can only set one Organization specific Reply-to Name and Email address in the "Organization Information" and then if needed override that information inside each email inside a program.
While this works, there are many places to change this and frequently this causes something to be missed in every single spot it could be done.
I have noticed a lot of clients have asked me for a program specific email override and I think it would make the most sense under the "General Information":

This email override could function much like the other program specific functions and should change the from email and name for :
- Confirmation Emails
- Emails in the custom email configuration
- LOR emails
- Email blast emails
While I could see this being a non trivial change from a code stand point, I know that a number of users that I deal with would love this feature and feel others would as well.